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Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB
Nature Aging (2023).

Longevity factor klotho enhances cognition in aged nonhuman primates
Castner SA, Gupta S, Wang D, Moreno AJ, Park C, Chen C, Poon Y, Groen A, Greenberg K, David N, Boone T, Baxter MG, Williams GV, Dubal DB
Nature Aging (2023);, doi: 10.1038/s43587-023-00441-x

X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain
Shaw CK, Abdulai-Saiku S, Marino F, Wang D, Davis EJ, Panning B, Dubal DB
The Journals of Gerontology: Series A, 2023;, glad007, doi: 10.1093/gerona/glad007

Rare APOE Missense Variants—Can We Overcome APOE ε4 and Alzheimer Disease Risk?
Rabinovici GD, Dubal DB
JAMA Neurology (2022);79(7):649-651. doi:10.1001/jamaneurol.2022.085

KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice
Gupta S, Moreno AJ, Wang D, Leon J, Chen C, Hahn O, Poon Y, Greenberg K, David N, Wyss-Coray T, Raftery D, Promislow DEL, Dubal DB
Journal of Neuroscience 11 May 2022, 42 (19) 4016-4025; DOI:

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease
Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB
JAMA Neurology (2021) Oct;78(10):1249-1254. doi:10.1001/jamaneurol.2021.2806

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease
Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB.
Sci Transl Med. 2020 Aug 26;12(558):eaaz5677. doi: 10.1126/scitranslmed.aaz5677.

Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4
Dubal DB, Yokoyama JS.
JAMA Neurology (2020) Jul 1;77(7):798-800. doi: 10.1001/jamaneurol.2020.0112.

Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning
Casaletto KB, Lindbergh C, Memel M, Staffaroni A, Elahi F, Weiner-Light S, You M, Fonseca C, Karydas A, Jacobs E, Dubal DB, Yaffe K, Kramer JH.
Brain Behav Immun. 2020 Aug;88:699-710. doi: 10.1016/j.bbi.2020.05.014. Epub 2020 May 6.

Sex difference in Alzheimer’s disease: An updated, balanced and emerging perspective on differing vulnerabilities
Dubal DB.
Handb Clin Neurol. 2020;175:261-273. doi: 10.1016/B978-0-444-64123-6.00018-7.

Pathways to brain resilience
Dubal DB.
Nature Medicine (2019) Jul;25(7):1027. doi: 10.1038/s41591-019-0502-7.

Neural-Derived Extracellular Vesicles in Clinical Trials
Dubal DB, Pleasure SJ.
JAMA Neurology (2019) Apr 1;76(4):402-404. doi: 10.1001/jamaneurol.2018.4325.

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.
Neurology. 2019 Mar 13; doi: 10.1212/WNL.0000000000007323

Female XX sex chromosomes increase survival and extend lifespan in aging mice
Davis EJ, Lobach I, Dubal DB.
Aging Cell. 2018 Dec 17; doi: 10.1111/acel.12871.

Ovarian Cycle Stages Modulate Alzheimer- Related Cognitive and Brain Network Alterations in Female Mice
Broestl L, Worden K, Moreno AJ, Davis EJ, Wang D, Garay B, Singh T, Verret L, Palop JJ, Dubal DB.
eNeuro. 2018 Dec 3; doi:

Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
Wojcicki JM, Prather AA, Epel E, Wang D, Dubal DB.
Journal of Pediatric Endocrinology and Metabolism. 2018 Apr 12; doi:

Apolipoprotein E ε4 and Risk Factors for Alzheimer Disease-Let’s Talk About Sex.
Dubal DB, Rogine C.
JAMA Neurology. 2017 Aug 28; doi: 10.1001/jamaneurol.2017.1470.

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice
Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB.
Cell Reports 2017 Aug 8; 20(6):1360-1371.

Longevity factor klotho and chronic psychological stress
Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB.
Translational Psychiatry. 2015;5:e585. doi:10.1038/tp.2015.81. Epub 2015 June 16.

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice
Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L.
J Neurosci. 2015 Feb 11;35(6):2358-71.

Variation in longevity gene KLOTHO is associated with greater cortical volumes
Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB
Ann Clin Transl Neurol. 2015 Mar;2(3):215-30. doi: 10.1002/acn3.161. Epub 2015 Jan 26.

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L
Nature Neuroscience 2015 Mar;18(3):423-34. doi: 10.1038/nn.3930. Epub 2015 Jan 26.

Life extension factor klotho enhances cognition
Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilerston KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L.
Cell Reports 2014 May 22; 7(4) 1-12. Epub 2014 May 8.

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
Dubal DB, Broestl L, Worden K.
Biol Sex Differ. 2012 Nov 5; 3(1):24. Epub 2012 Nov 5.

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L.
PLoS One. 2012;7(9):e45881. doi: 10.1371/journal.pone.0045881. Epub 2012 Sep 24.

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L.
Nature. 2011 Jan 6;469(7328):47-52. Epub 2010 Nov 28.

T-cell lymphoproliferative disorder following mycophenolate treatment for myasthenia gravis.
Dubal DB, Mueller S, Ruben BS, Engstrom JW, Josephson SA.
Muscle Nerve. 2009 Jun;39(6):849-50.

Collagen VI protects neurons against Abeta toxicity.
Cheng JS*, Dubal DB* (co-first author), Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L.
Nature Neuroscience 2009 Feb;12(2):119-21. Epub 2009 Jan 4.

A case of paraneoplastic myelopathy associated with the neuromyelitis optica antibody.
Mueller S, Dubal DB, Josephson SA.
Nat Clin Pract Neurol. 2008 May;4(5):284-8. Epub 2008 Mar 4.

Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death.
Dubal DB*, Rau SW* (co-first author), Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Bottner MB, Dubal SB, Merchanthaler I, Kindy MS, Wise PM.
Endocrinology. 2006 Jun;147(6):3076-84. Epub 2006 Mar 9.

Stroke injury in rats causes an increase in activin A gene expression which is unaffected by oestradiol treatment.
Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM.
J Neuroendocrinol. 2006 Feb;18(2):97-103.

Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women’s health initiative.
Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S.
Endocr Rev. 2005 May;26(3):308-12. Epub 2005 Apr 25. Review.

Estradiol attenuates programmed cell death after stroke-like injury.
Rau SW, Dubal DB, Böttner M, Gerhold LM, Wise PM.
J Neurosci. 2003 Dec 10;23(36):11420-6.

Estradiol differentially regulates c-Fos after focal cerebral ischemia.
Rau SW, Dubal DB, Böttner M, Wise PM.
J Neurosci. 2003 Nov 19;23(33):10487-94.

Ms Jones: reflections on aging, illness, and medicine.
Dubal D.
Fam Med. 2003 Mar;35(3):165-6. No abstract available.

Estradiol: a protective and trophic factor in the brain.
Dubal DB, Wilson ME, Wise PM.
J Alzheimers Dis. 1999 Nov;1(4-5):265-74.

Estrogen and neuroprotection: from clinical observations to molecular mechanisms.
Dubal DB, Wise PM.
Dialogues Clin Neurosci. 2002 Jun;4(2):149-61.

Neuroendocrine modulation and repercussions of female reproductive aging.
Wise PM, Smith MJ, Dubal DB, Wilson ME, Rau SW, Cashion AB, Böttner M, Rosewell KL.
Recent Prog Horm Res. 2002;57:235-56. Review.

Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies.
Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL.
Brain Res Brain Res Rev. 2001 Nov;37(1-3):313-9. Review.

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury.
Wise PM, Dubal DB, Wilson ME, Rau SW.
J Neurocytol. 2000 May-Jun;29(5-6):401-10. Review.

Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action.
Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M.
Endocrinology. 2001 Mar;142(3):969-73. Review.

Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury.
Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM.
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1952-7. Epub 2001 Feb 6.

Neuroprotective effects of estradiol in middle-aged female rats.
Dubal DB, Wise PM.
Endocrinology. 2001 Jan;142(1):43-8.

Estrogens: trophic and protective factors in the adult brain.
Wise PM, Dubal DB, Wilson ME, Rau SW, Liu Y.
Front Neuroendocrinol. 2001 Jan;22(1):33-66. Review.

Estradiol protects against ischemic brain injury in middle-aged rats.
Wise PM, Dubal DB.
Biol Reprod. 2000 Oct;63(4):982-5.

Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors.
Wilson ME, Dubal DB, Wise PM.
Brain Res. 2000 Aug 11;873(2):235-42.

Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors.
Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM.
J Neurosci. 1999 Aug 1;19(15):6385-93.

Neuroendocrine influences and repercussions of the menopause.
Wise PM, Smith MJ, Dubal DB, Wilson ME, Krajnak KM, Rosewell KL.
Endocr Rev. 1999 Jun;20(3):243-8. Review.

Estradiol protects against ischemic injury.
Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM.
J Cereb Blood Flow Metab. 1998 Nov;18(11):1253-8.